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Authors: Vanessa Ngan, Staff Writer, 2003. Updated: Dr Kelvin Truong, Dermatology Research Fellow, Westmead Hospital, Sydney, Australia. Copy edited by Gus Mitchell. October 2021
Mycophenolate mofetil is the prodrug form of mycophenolic acid, a potent immunosuppressive drug. Enteric-coated mycophenolate sodium is another form of mycophenolic acid used in clinical practice.
Mycophenolate mofetil is an immunosuppressant approved for to prevent rejection of solid organ (kidney, liver, heart) transplants.
Off-label use of mycophenolate mofetil is widespread in dermatology.
Immunobullous diseases that may be treated with mycophenolate mofetil
Mycophenolate mofetil is available in oral and intravenous formulations.
A typical starting dose used in dermatology is 250 mg twice daily. If no improvement is observed after one month of therapy, the dose may be increased by 500 milligram increments up to a maximum of 3 g per day.
Dose reduction is required with chronic renal insufficiency as mycophenolic acid is mostly excreted via the kidneys.
Mycophenolate mofetil is often used in combination with other immunosuppressive drugs [see Drug-induced immunosuppression]
Mycophenolate mofetil can increase the risk of these skin infections
Mycophenolate mofetil should be ceased if pregnancy occurs or:
Bone marrow suppression, if mild, usually recovers with dose reduction or cessation of the mycophenolate mofetil.
If you are not based in New Zealand, we suggest you refer to your national drug approval agency for further information about medicines (eg, the Australian Therapeutic Goods Administration and the US Food and Drug Administration) or a national or state-approved formulary (eg, the New Zealand Formulary and New Zealand Formulary for Children and the British National Formulary and British National Formulary for Children).
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